Key result
In an in situ porcine model of acute ischemia, the steady-state rate-dependent component of intraventricular conduction slowing occurred without a rate-dependent component in the rise of extracellular potassium.
Population
9 anesthetized open chest pigs in which acute no-flow ischemia was induced by occlusion of the left anterior…
Comparison
Stimulation at varying rates from 90 to 150… vs Different stimulation rates (90 vs 150 beats/min)
Design
Preclinical
Authors
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Challenges role of extracellular potassium in ischemic conduction slowing; hypothesis-generating for mechanistic human studies.
In an in situ pig heart model of acute ischemia, the rate-dependent slowing of intraventricular conduction occurs independently of changes in extracellular potassium concentration.
HARPER et al. (1993) studied Acute regional no-flow ischemia (n=9). Variation of stimulation rate (90 to 150 beats/min) was evaluated on Rate dependence of slowing of longitudinal intraventricular conduction and rise in extracellular potassium concentration ([K+]e). In an in situ porcine model of acute ischemia, the steady-state rate-dependent component of intraventricular conduction slowing occurred without a rate-dependent component in the rise of extracellular potassium.
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