Key result
Intracoronary isoproterenol infusion in pigs caused a monovalent cation shift that was not associated with reduced contractility, but could explain the 12% undershoot of LV dP/dt after stopping.
Why the study?
Does intracoronary isoproterenol infusion alter the temporal relationship between cardiac contractility and myocardial potassium balance in an open-chest pig model?
Population
8 open-chest pigs
Comparison
Intracoronary isoproterenol infusion vs Baseline and after stopping infusion
Design
Preclinical
Follow-up
Minutes (during and up to 8 minutes after stopping infusion)
Authors
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Cation shifts may underlie post-isoproterenol LV dP/dt undershoot in pigs; leaves open human relevance and clinical translation.
Does intracoronary isoproterenol infusion alter the temporal relationship between cardiac contractility and myocardial potassium balance in an open-chest pig model?
Effect estimate: 12% lower (95% CI 9-24)
p-value: p=<0.02
The monovalent cation shift following the positive inotropic response to isoproterenol is not associated with reduced contractility during infusion, but may explain the undershoot of LV dP/dt after stopping the drug.
Ellingsen et al. (1988) studied this question. Intracoronary isoproterenol infusion vs. Baseline (before infusion) was evaluated on LV dP/dt after stopping isoproterenol (12% lower, 95% CI 9-24, p=<0.02). Intracoronary isoproterenol infusion in pigs caused a monovalent cation shift that was not associated with reduced contractility, but could explain the 12% undershoot of LV dP/dt after stopping.
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