Key result
Left-side isoproterenol reduces LV preejection segment length by ~3% and increases stroke volume in pigs.
Population
Open-chest pigs (17-36 kg) anesthetized with pentobarbital sodium
Comparison
Continuous infusions of isoproterenol and… vs Baseline and normovolemia vs hypervolemia
Design
Preclinical
Authors
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May augment RV output via LV-RV interaction in acute models; leaves open translation to human biventricular failure.
p-value: p=<0.01
Selective left ventricular inotropic stimulation reduces right ventricular afterload, which appears to be an important mechanism for increasing right ventricular output.
Vengen et al. (1987) studied this question. Isoproterenol and calcium chloride was evaluated on Stroke volume and left ventricular preejection segment length (p=<0.01). Left-side inotropic stimulation with isoproterenol reduced left ventricular preejection segment length by 3.2% (P<0.01) and increased stroke volume by 1.2 ml (P<0.01) in open-chest pigs.
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