Population
Isolated, cylindrical papillary muscles of the rabbit, blood-perfused through their vascular tree
Comparison
Ischemia produced by total arrest of perfusion… vs Different muscle geometries and baseline…
Design
Preclinical
Follow-up
10 minutes of ischemia
Authors
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Size-dependent K+ gradients during ischemia may promote arrhythmias; hypothesis-generating in rabbit models, needs in vivo confirmation.
In isolated rabbit myocardium, local accumulation and diffusion of CO2 during early ischemia significantly influence extracellular potassium accumulation, creating gradients that may contribute to ventricular arrhythmias.
Cascio et al. (1992) studied this question.