Why the study?
Does ischemic preconditioning alter the onset and duration of electrical uncoupling during ischemia in failing rabbit ventricular myocardium compared to normal myocardium?
Population
Arterially perfused right ventricular papillary muscles from 26 rabbits.
Comparison
Ischemic preconditioning before sustained ischemia vs Control perfusion before sustained ischemia
Design
Preclinical
Authors
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May caution against preconditioning in failing myocardium; leaves open translation to human ischemia.
Does ischemic preconditioning alter the onset and duration of electrical uncoupling during ischemia in failing rabbit ventricular myocardium compared to normal myocardium?
Ischemic preconditioning may have detrimental effects in severely failing myocardium by advancing the moment of irreversible ischemic damage, contrasting with its protective effects in normal hearts.
Dekker et al. (1998) studied this question.
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