Balloon injury and interleukin-1 beta induce nitric oxide synthase activity in rat carotid arteries.
Key result
In vivo balloon injury of rat carotid arteries induces the production of nitric oxide from L-arginine in the blood vessel wall, an effect which is potentiated by interleukin-1 beta.
Why the study?
Does balloon injury and interleukin-1 beta induce nitric oxide synthase activity in rat carotid arteries?
Population
Rat carotid arteries
Comparison
Balloon catheterization injury and interleukin-1… vs Control right carotid arteries
Design
Preclinical
Follow-up
24 hours
Authors
Discussion
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Member takes
Implication
Indicates NOS induction in injured rat arteries; leaves open relevance to human vascular injury responses.
Structured PICO
Does balloon injury and interleukin-1 beta induce nitric oxide synthase activity in rat carotid arteries?
P
Population
Rat carotid arteries
I
Intervention
Balloon catheterization injury (evaluated at 0, 6, and 24 hours) and interleukin-1 beta exposure
C
Comparator
Control right carotid arteries (with and without endothelium)
O
Outcome
Nitric oxide synthase activity (measured by contractions to phenylephrine and basal level of cGMP)surrogate
Balloon injury to rat carotid arteries induces nitric oxide synthase activity, which is further potentiated by interleukin-1 beta, suggesting a mechanism for altered vascular reactivity following endothelial injury.
Cite This Study
Joly et al. (1992) studied Endothelial injury. Balloon injury and interleukin-1 beta vs. Control right carotid arteries (with and without endothelium) was evaluated on Nitric oxide synthase activity (contractions to phenylephrine and cGMP levels). In vivo balloon injury of rat carotid arteries induces the production of nitric oxide from L-arginine in the blood vessel wall, an effect which is potentiated by interleukin-1 beta.