What question did this study set out to answer?

To evaluate hemostatic and inflammatory markers in children with newly diagnosed acute lymphoblastic leukemia (ALL) at diagnosis and during chemotherapy.

January 27, 2010American Journal of HematologyOpen Access

Prospective study of hemostatic alterations in children with acute lymphoblastic leukemia

View Full Paper

Ask AI

Bookmark

Authors

PGPaola GiordanoCystic Fibrosis Trust AMAngelo Claudio MolinariIstituto Giannina Gaslini GVGiancarlo VecchioQueen Mary University of London

Discussion

Member takes

Implication

Prospective study evaluates hemostatic alterations during chemotherapy in children with acute lymphoblastic leukemia, suggesting vascular impacts.

Key Points

To evaluate hemostatic and inflammatory markers in children with newly diagnosed acute lymphoblastic leukemia (ALL) at diagnosis and during chemotherapy.
Evaluated plasma hemostatic markers at diagnosis and during chemotherapy at multiple time points (T0, T1, T2, T3).
Analyzed levels of thrombin-antithrombin complex, D-Dimer, PAI-1, fibrinogen, VWF, P-selectin, TNF-alpha, and IL-6.
Collected samples at baseline and post-therapy intervals during the remission induction phase.
Children with ALL showed increased thrombin and fibrin markers at diagnosis (high TAT and D-Dimer).
Thrombin markers and inflammatory cytokines decreased after starting induction therapy, while PAI-1 and P-selectin increased.
Two cases of symptomatic venous thromboembolism developed during induction therapy.

Cite This Study

Giordano et al. (2010) studied this question.

synapsesocial.com/papers/6a202d3beab213b7bb294748 https://doi.org/10.1002/ajh.21665

View Full Paper

Ask AI

Bookmark

Implication

Prospective study evaluates hemostatic alterations during chemotherapy in children with acute lymphoblastic leukemia, suggesting vascular impacts.

Prospective study of hemostatic alterations in children with acute lymphoblastic leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

Prospective study of hemostatic alterations in children with acute lymphoblastic leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider