What is the clinical evidence from this study?

Study design: Review. Population: Striated muscle contraction.

January 1, 2015Proceedings of the Japan Academy Series BOpen Access

Mechanism of the calcium-regulation of muscle contraction — In pursuit of its structural basis —

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Key result

Calcium regulates striated muscle contraction through structural changes where the troponin arm binds actin at low calcium levels, causing tropomyosin to block myosin-binding sites.

Population

Striated muscle (basic science model)

Comparison

Calcium ions vs Calcium-depleted state

Design

Review

Authors

TWTakeyuki WakabayashiThe University of Tokyo

Discussion

Member takes

Implication

Supports cardiac contraction models; leaves open targeted therapies for contractile disorders.

Structured PICO

Population

Striated muscle (basic science model)

Intervention

Calcium ions

Comparator

Calcium-depleted state

Outcome

Structural changes in troponin and tropomyosin leading to muscle contractionsurrogate

This review elucidates the structural mechanism by which calcium regulates striated muscle contraction via conformational changes in the troponin-tropomyosin complex.

Cite This Study

Takeyuki Wakabayashi (2015) conducted a review in Striated muscle contraction. Calcium regulates striated muscle contraction through structural changes where the troponin arm binds actin at low calcium levels, causing tropomyosin to block myosin-binding sites.

synapsesocial.com/papers/6a202dba6ed993cb49fbff99 https://doi.org/10.2183/pjab.91.321

View Full Paper

Ask AI

Bookmark

Mechanism of the calcium-regulation of muscle contraction — In pursuit of its structural basis —

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanism of the calcium-regulation of muscle contraction — In pursuit of its structural basis —

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider