Key result
Ca2+ dissociation induces closing of the cTnC N-domain in one step (t1/2 ~5 ms), while other structural transitions are biphasic and slower than regulatory Ca2+ release (t1/2 3.6 ms).
The study defines the kinetics and magnitudes of structural changes in cardiac troponin relevant to Ca2+ switching between activation and deactivation of cardiac muscle contraction.
These kinetics refine cardiac contraction models in animals; leaves open translation to human Ca2+ handling and therapies.
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Dong et al. (2003) studied this question. Ca2+ dissociation vs. Ca2+ bound state was evaluated on Kinetics of conformational transitions in cardiac troponin. Ca2+ dissociation induces closing of the cTnC N-domain in one step (t1/2 ~5 ms), while other structural transitions are biphasic and slower than regulatory Ca2+ release (t1/2 3.6 ms).
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