What does this research mean for the field?

USP5 promotes immune escape in melanoma by deubiquitinating and stabilizing PD-L1, and its inhibition enhances the efficacy of anti-PD-1 immunotherapy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 10, 2025Journal of Translational MedicineOpen Access

USP5-Mediated PD-L1 deubiquitination regulates immunotherapy efficacy in melanoma

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JXJiaheng Xie PZPengpeng Zhang YLYuankun Liu

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Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/6a202eb7eab213b7bb294a1d https://doi.org/10.1186/s12967-025-06812-9

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July 10, 2025Journal of Translational MedicineOpen Access

USP5-Mediated PD-L1 deubiquitination regulates immunotherapy efficacy in melanoma

View Full Paper

Ask AI

Bookmark

Authors

JXJiaheng Xie PZPengpeng Zhang YLYuankun Liu

Discussion

Member takes

Overview

Key Points

Key points are not available for this paper at this time.

Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/6a202eb7eab213b7bb294a1d https://doi.org/10.1186/s12967-025-06812-9

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