Long-term association of pericardial adipose tissue with incident diabetes and prediabetes: the Coronary Artery Risk Development in Young Adults Study

Figures

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  Figure 1.. ROC curves of unadjusted (A) and fully adjusted (B) models for PAT versus WC, BMI, WHtR, fasting glucose at exam year 15 in predicting diabetes (1) and prediabetes (2) status 5, 10, and 15 years later, the CARDIA Study (2000-2016). The fully adjusted model adjusted for sex, race, center, age at year 15, education and occupation status at year 30, smoking status at year 30, averages (exam years 15, 20, 25, and 30) of moderate-to-vigorous intensity physical activity, alcohol consumption, systolic blood pressure, diastolic blood pressure, total cholesterol, high-density lipoprotein-cholesterol, diet quality score derived from exam years 0, 7, and/or 20, antihypertensive and lipid-lowering medication use at year 15, and family history of diabetes at year 25. Values are presented as AUC (95% confidence interval). ROC, receiver operating characteristic; WC, waist circumference; WHtR, waist-to-height ratio; AUC, area under the ROC curve; PAT, pericardial adipose tissue; BMI, body mass index; CARDIA, Coronary Artery Risk Development in Young Adults. *p<0.05, statistically significant difference with PAT.

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  Figure 2.. ROC curves of WC (A), BMI (B), and WHtR (C) with additional adjustment for PAT at exam year 15 in predicting diabetes (1) and prediabetes (2) status 5, 10, and 15 years later, the CARDIA Study (2000-2016). All models adjusted for sex, race, center, age at year 15, education and occupation status at year 30, smoking status at year 30, averages (exam years 15, 20, 25, and 30) of moderate-to-vigorous intensity physical activity, alcohol consumption, systolic blood pressure, diastolic blood pressure, total cholesterol, high-density lipoprotein-cholesterol, diet quality score derived from exam years 0, 7, and/or 20, antihypertensive and lipid-lowering medication use at exam year 15, and family history of diabetes at exam year 25. Values are presented as AUC (95% confidence interval). p-values indicate statistically significant differences with PAT. ROC, receiver operating characteristic; WHtR, waist-to-height ratio; AUC, area under the ROC curve; PAT, pericardial adipose tissue; WC, waist circumference; BMI, body mass index; CARDIA, Coronary Artery Risk Development in Young Adults.