Key result
High levels of epicardial adipose tissue (> median) were associated with a 46% increased risk of incident cardiovascular disease and all-cause mortality in patients with type 2 diabetes (HR 1.46).
Why the study?
Cardiac fat is a cardiovascular biomarker, but its importance in patients with type 2 diabetes is not clear.
Does high epicardial adipose tissue predict incident cardiovascular disease and mortality in patients with type 2 diabetes?
Population
1030 patients with type 2 diabetes
Comparison
High EAT (> median level) vs lower EAT levels, alongside PAT and CAT
Design
Prospective cohort study
Follow-up
Median 4.7 years
Authors
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High EAT was associated with higher CVD/mortality risk in T2D; hypothesis-generating for risk stratification and requires prospective validation.
Cohort (n=1,030)
Yes
Does high epicardial adipose tissue predict incident cardiovascular disease and mortality in patients with type 2 diabetes?
Hazard Ratio: 1.46 (95% CI 1.13–1.88)
p-value: p=0.004
High epicardial adipose tissue measured by echocardiography modestly improves cardiovascular risk prediction beyond traditional risk factors in patients with type 2 diabetes, particularly in men.
Christensen et al. (2019) conducted a cohort in Type 2 diabetes (n=1,030). High epicardial adipose tissue (EAT) vs. Low epicardial adipose tissue (EAT) was evaluated on Composite of incident cardiovascular disease (CVD) and all-cause mortality (HR 1.46, 95% CI 1.13; 1.88, p=0.004). High levels of epicardial adipose tissue (> median) were associated with a 46% increased risk of incident cardiovascular disease and all-cause mortality in patients with type 2 diabetes (HR 1.46).
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