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January 29, 2021Open Access

Epicardial adipose tissue volume and coronary calcification among people living with diabetes: a cross-sectional study

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Why the study?

Epicardial adipose tissue is considered a novel marker and target in cardiometabolic diseases, but whether its volume is independently associated with coronary artery calcification in diabetes required evaluation.

Population

409 consecutive patients with diabetes at a single centre in France

Comparison

Coronary artery calcification score ≥ 100 AU vs < 100 AU across EAT volumes

Design

Cross-sectional study

Authors

ECEmmanuel CossonMNM.T. NguyenIRI. Rezgani

Discussion

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Overview

Association between EAT volume and CAC in diabetes warrants prospective validation; does not yet support routine clinical use.

Structured PICO

P
Population
409 consecutive patients with diabetes (318 type 2, 56 type 1, 35 other), mean age 57±12 years, 218 men (53%), mean BMI 29±6 kg/m², admitted to a single hospital department in France.
I
Intervention
Epicardial adipose tissue (EAT) volume measurement via computed tomography (exposure)
O
Outcome
Coronary artery calcification (CAC) score ≥ 100 Agatston units (AU)surrogate

Epicardial adipose tissue volume is independently associated with subclinical coronary atherosclerosis (CAC ≥ 100 AU) in patients with diabetes, suggesting it may serve as a useful marker for cardiovascular risk.

Limitations

  • Observational design prevents causal conclusions
  • Used surrogate marker (CAC) instead of clinical cardiovascular events
  • Single-center hospital cohort may not be representative of all patients with diabetes
  • Lack of data on waist circumference

Cite This Study

Cosson et al. (2021) studied this question.

synapsesocial.com/papers/6a70da5f6ceb2bbd16e004a0https://doi.org/10.21203/rs.3.rs-130640/v2
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