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December 22, 2020Open Access

Epicardial adipose tissue volume and coronary calcification among people living with diabetes: a cross-sectional study

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Why the study?

Epicardial adipose tissue is considered a novel diagnostic marker and therapeutic target in cardiometabolic diseases, but whether its volume is associated with coronary artery calcification in people living with diabetes independently of confounding factors required evaluation.

Population

409 consecutive patients with diabetes at a single hospital in France

Comparison

Epicardial adipose tissue volume across coronary artery calcification categories

Design

Single-centre cross-sectional study

Authors

ECEmmanuel CossonMNM.T. NguyenIRI. Rezgani

Discussion

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Overview

EAT volume may aid CAC risk stratification in diabetes; leaves open causal role and requires prospective validation.

Structured PICO

P
Population
409 consecutive patients with diabetes (318 type 2, 56 type 1, 35 other), mean age 57 ± 12 years, 218 men, mean BMI 29 ± 6 kg/m², admitted to a single center in France.
O
Outcome
Coronary artery calcification (CAC) score ≥ 100 Agatston units (AU)surrogate

Epicardial adipose tissue volume is independently associated with subclinical coronary atherosclerosis (CAC ≥ 100 AU) in patients with diabetes, suggesting its potential utility as a marker for cardiovascular risk.

Limitations

  • Observational design prevents causal conclusions
  • Unable to conclude on the role of therapy on EAT volume
  • Used a surrogate marker of subclinical atherosclerosis (CAC) instead of cardiovascular events
  • Single-center hospital-admitted cohort may not be representative of all patients with diabetes
  • Lack of data on waist circumference

Cite This Study

Cosson et al. (2020) studied this question.

synapsesocial.com/papers/6a70da5f6ceb2bbd16e004a1https://doi.org/10.21203/rs.3.rs-130640/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis2008 · 228 citations
  2. 2Association of Epicardial Adipose Tissue and High‐Risk Plaque Characteristics: A Systematic Review and Meta‐Analysis2017 · 166 citations
  3. 3Impaired Coronary Endothelium-Dependent Vasodilation Is Associated With Microalbuminuria in Patients With Type 2 Diabetes and Angiographically Normal Coronary Arteries2006 · 9 citations
  4. 4Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis2019 · 134 citations
  5. 5Effects of antidiabetic drugs on epicardial fat2018 · 23 citations