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February 5, 2021Cardiovascular DiabetologyOpen Access

Epicardial adipose tissue volume and coronary calcification among people living with diabetes: a cross-sectional study

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Why the study?

Epicardial adipose tissue is considered a novel diagnostic marker and therapeutic target in cardiometabolic diseases, but whether its volume is independently associated with coronary artery calcification in people with diabetes required evaluation.

Is epicardial adipose tissue volume associated with coronary artery calcification in patients with diabetes?

Population

409 consecutive patients with diabetes at a single hospital in France

Comparison

Association between epicardial adipose tissue volume and CAC score

Design

Cross-sectional study

Authors

ECEmmanuel CossonMNM.T. NguyenIRI. Rezgani

Discussion

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Member takes

Overview

EAT volume may mark CAC risk in diabetes; hypothesis-generating and requires prospective validation before clinical use.

Structured PICO

Is epicardial adipose tissue volume associated with coronary artery calcification in patients with diabetes?

P
Population
409 consecutive patients with diabetes (318 type 2, 56 type 1, 35 other) admitted to a hospital department in France, mean age 57.1, 218 men.
O
Outcome
Coronary artery calcification (CAC) score ≥ 100 Agatston unitssurrogate

Epicardial adipose tissue volume is independently associated with coronary artery calcification in patients with diabetes, suggesting it may serve as a surrogate marker for subclinical coronary atherosclerosis.

Limitations

  • Observational design preventing causal conclusions
  • Inability to conclude on the role of therapy on EAT volume
  • Use of a surrogate marker (CAC) instead of cardiovascular events
  • Single-center cohort that may not be representative
  • Lack of data on waist circumference

Cite This Study

Cosson et al. (2021) studied this question.

synapsesocial.com/papers/6a70da5f6ceb2bbd16e0049fhttps://doi.org/10.1186/s12933-021-01225-6
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