Pigment epithelium-derived factor and osteopontin protect human retinal pigment epithelial cells from oxidative stress in 2D and 3D models

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Exogenous supplementation with pigment epithelium-derived factor (PEDF) and osteopontin (OPN) protects human retinal pigment epithelial cells from oxidative stress-induced damage. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Samira Karami; Pascale Charpentier; Solange Landreville; Stéphanie Proulx

doi:10.1016/j.freeradbiomed.2026.02.034

February 13, 2026Free Radical Biology and MedicineOpen Access

Pigment epithelium-derived factor and osteopontin protect human retinal pigment epithelial cells from oxidative stress in 2D and 3D models

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Abstract

-induced oxidative stress damage. In 3D TECS, CMs secreted insufficient levels of PEDF and OPN for RPE cells to manage oxidative stress-induced damage. These findings demonstrate that exogenous supplementation with PEDF and OPN proteins may be beneficial for oxidative-stress related eye diseases.

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Karami et al. (2026) studied this question.

synapsesocial.com/papers/6a20345645d96add4db5cc84 https://doi.org/10.1016/j.freeradbiomed.2026.02.034

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Pigment epithelium-derived factor and osteopontin protect human retinal pigment epithelial cells from oxidative stress in 2D and 3D models

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Pigment epithelium-derived factor and osteopontin protect human retinal pigment epithelial cells from oxidative stress in 2D and 3D models

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Abstract

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