The Familial Occurrence of Hypertension and Coronary Artery Disease, With Observations Concerning Obesity and Diabetes

Article1 January 1955THE FAMILIAL OCCURRENCE OF HYPERTENSION AND CORONARY ARTERY DISEASE, WITH OBSERVATIONS CONCERNING OBESITY AND DIABETESCAROLINE BEDELL THOMAS, F.A.C.P., BERNICE HIRSCHHORN COHENCAROLINE BEDELL THOMAS, F.A.C.P., BERNICE HIRSCHHORN COHENAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-1-90 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI. INTRODUCTIONIt is commonly thought that certain families are afflicted with high blood pressure, strokes and heart attacks with unwarranted frequency and to a severe degree. Sudden death may occur repeatedly in successive generations as a consequence of hypertension, coronary artery disease, or both. Yet, although these disorders are among the major causes of death in many countries today, no certainty exists as to whether such familial catastrophes arise in response to a hereditary pattern, as a result of a particular upbringing and way of life, as an extreme example of the vagaries of chance, or, indeed, from some...Bibliography1. ForestusDewees PWP: Practice of physic, Vol. I, Chapter 8, 1830, Carey and Lea, Philadelphia. Google Scholar2. Morgagni JB: The seats and causes of diseases investigated by anatomy, Vol. I, London, 1769. Google Scholar3. Gates RR: Human genetics, Vol. I, 1946, The Macmillan Co., New York, p. 659. Google Scholar4. Søbye P: Heredity in essential hypertension and nephrosclerosis, a genetic-clinical study of 200 propositi suffering from nephrosclerosis, 1948, Arnold Busck, Copenhagen. Google Scholar5. Platt R: Heredity in hypertension, Quart. J. Med. 16: 111, 1947. MedlineGoogle Scholar6. 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Snyder LH: Studies in human inheritance. X. A table to determine the proportion of recessives to be expected in various matings involving a unit character, Genetics 19: 1, 1934. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication May 17, 1954.From The Johns Hopkins University School of Medicine, Baltimore.†This study was supported in part by Research Grant 215, the United States Public Health Service, Federal Security Agency, and in part by Research Contract V1001M-2768, Veterans Administration. 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A study from the collaborative perinatal project*REFERENCESArteriosclerotic aneurysms of the abdominal aorta: A reviewCoronary Heart Disease in Young Men: A Study of Seventy Patients with a Critical Review of Etiological Factors*REFERENCESGeneralized seizures following isoniazid therapy for tuberculosis in a patient with uremiaClinical DiagnosisFamilial Hypercholesterolemia in a Large Kindred Evidence for a Monogenic MechanismHELMUT G. SCHROTT, M.D., JOSEPH L. GOLDSTEIN, M.D., WILLIAM R. HAZZARD, M.D., MICHAEL M. MCGOODWIN, M.D., ARNO G. 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BORNHOLDHYPERTENSIONA Comparative Study of Myocardial Infarction in the White and Negro Races 1 January 1955Volume 42, Issue 1Page: 90-127KeywordsHypertensionMedical servicesMyocardial infarctionObesityPrimary hypertensionResearch grantsStable coronary artery diseaseStroke ePublished: 1 December 2008 Issue Published: 1 January 1955 PDF downloadLoading ...