November 6, 2014PLoS ONEOpen Access

Exercise-Mediated Wall Shear Stress Increases Mitochondrial Biogenesis in Vascular Endothelium

View Full Paper

Ask AI

Bookmark

Why the study?

Does exercise-mediated wall shear stress increase mitochondrial biogenesis in vascular endothelium?

Structured PICO

Does exercise-mediated wall shear stress increase mitochondrial biogenesis in vascular endothelium?

Population

Human aortic endothelial cells (HAECs), human umbilical vein endothelial cells (HUVECs), and 20 inbred C57Bl/6J mice (8-10 weeks old).

Intervention

Laminar shear stress (20 dyne/cm2) in vitro; voluntary wheel running exercise for 5 weeks in vivo.

Comparator

Static conditions (STT) in vitro; sedentary (SED) control mice in vivo.

Outcome

Mitochondrial biogenesis (expression of key genes, mtDNA content, mitochondrial mass) and mitochondrial respiratory function.surrogate

Exercise enhances mitochondrial biogenesis in vascular endothelium through a shear stress-dependent mechanism, suggesting a novel pathway for the vascular benefits of chronic exercise.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating in mice; leaves open whether shear stress drives endothelial mitochondrial biogenesis in humans.

Cite This Study

Kim et al. (2014) studied this question.

synapsesocial.com/papers/6a20357360a84f4b7dd8dfd7 https://doi.org/10.1371/journal.pone.0111409

View Full Paper

Ask AI

Bookmark

Exercise-Mediated Wall Shear Stress Increases Mitochondrial Biogenesis in Vascular Endothelium

Structured PICO

Discussion

Implication

Cite This Study

Exercise-Mediated Wall Shear Stress Increases Mitochondrial Biogenesis in Vascular Endothelium

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider