Key result
The MMP3 rs679620 A allele was associated with a significantly increased risk of hamstring injury (HR 2.06), though a multivariable genetic risk model lacked predictive ability in an independent validation cohort.
Why the study?
Do candidate single nucleotide polymorphisms predict noncontact hamstring muscle injuries in elite male soccer players?
Cohort (n=107)
No
Do candidate single nucleotide polymorphisms predict noncontact hamstring muscle injuries in elite male soccer players?
While certain genetic variants are associated with hamstring injuries in elite soccer players, they do not have sufficient independent predictive value to be used for clinical risk assessment.
Answers are grounded in this paper and cite their sources.
SNPs linked to higher hamstring injury risk lack predictive value for screening; hypothesis-generating for genetic models in athletes.
PURPOSE: This study aimed to investigate the association of candidate single nucleotide polymorphisms (SNP) with noncontact hamstring muscle injuries in elite soccer players and to create and validate a model to assess the risk of hamstring injury. METHODS: A total of 107 elite male outfield players were prospectively followed for six seasons. Players were genotyped for 37 SNP previously investigated in relation to musculoskeletal injuries. The association of SNP, previous injury, age, level of play, position, and anthropometric data with 129 hamstring injuries (413 observations) was investigated in the discovery phase (2010-2015), and a multivariable Cox frailty model was created using forward selection. The model's discriminative ability was tested in the validation phase (2015-2016, 31 injuries, 98 observations) using Harrell's C index. RESULTS: Five SNP were found to be significantly associated with hamstring injury in a multivariable model: matrix metalloproteinase 3 rs679620 (A vs G, hazard ratio [HR] = 2.06, 95% confidence interval [CI] = 1.51-2.81), tenascin C rs2104772 (A vs T, HR = 1.65, 95% CI = 1.17-2.32), interleukin 6 rs1800795 (GG vs GC + CC, HR = 1.68, 95% CI = 1.11-2.53), nitric oxide synthase 3 rs1799983 (G vs T, HR = 1.35, 95% CI = 1.01-1.79), and hypoxia-inducible factor-1α rs11549465 (CC vs CT, HR = 2.08, 95% CI = 1.00-4.29). Age also entered the model (≥24 vs <24 yr, HR = 2.10, 95% CI = 1.29-3.42). The model showed acceptable discrimination in the discovery phase (C index = 0.74), but not in the validation phase (C index = 0.52). CONCLUSION: Genetic variants appear to be involved in the etiology of hamstring injuries but were not found to have predictive value by themselves. Further research, increasing the number of genetic variants and including environmental factors in complex multifactorial risk models, is necessary.
No takes yet. Share an insight, caveat, or question.
Larruskain et al. (2017) conducted a cohort in Hamstring injury (n=107). Genetic variants (MMP3 rs679620 A allele) vs. G allele was evaluated on Non-contact hamstring muscle injuries (HR 2.06, 95% CI 1.51-2.81). The MMP3 rs679620 A allele was associated with a significantly increased risk of hamstring injury (HR 2.06), though a multivariable genetic risk model lacked predictive ability in an independent validation cohort.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: