Why the study?
High rates of sports injuries affect athlete health and performance, motivating evaluation of whether single nucleotide polymorphisms in various genes are associated with injuries in soccer.
Are single nucleotide polymorphisms associated with sports injuries in soccer practitioners?
Population
Soccer practitioners and supposedly healthy controls across 10 case-control studies
Comparison
Presence vs absence of single nucleotide polymorphisms in various genes
Design
Meta-analysis of case-control studies
Key result
Single nucleotide polymorphisms in ACTN3 (OR 0.98; 95% CI 0.64-1.50) and other genes were evaluated for their association with sports injuries in soccer practitioners.
Authors
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No association with ACTN3 or related SNPs; does not support genetic screening for soccer injury risk and challenges candidate-gene hypotheses.
Meta-Analysis (n=10)
Are single nucleotide polymorphisms associated with sports injuries in soccer practitioners?
Effect estimate: OR 0.98 (95% CI 0.64-1.50)
This meta-analysis found no significant association between specific SNPs (ACTN3, MMP, TIMP2, VEGFA) and sports injuries in soccer players based on the reported odds ratios.
Tobar et al. (2021) conducted a meta-analysis in Sports injuries in soccer (n=10). Single nucleotide polymorphisms (ACTN3, MMP, TIMP2, VEGFA) vs. Healthy controls was evaluated on Risk of sports injuries (OR 0.98, 95% CI 0.64-1.50). Single nucleotide polymorphisms in ACTN3 (OR 0.98; 95% CI 0.64-1.50) and other genes were evaluated for their association with sports injuries in soccer practitioners.