January 28, 2009Cardiovascular Research

Human cardiac gap-junction coupling: effects of antiarrhythmic peptide AAP10

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Why the study?

Does AAP10 improve gap-junctional intercellular coupling in human and rat cardiomyocytes?

Structured PICO

Does AAP10 improve gap-junctional intercellular coupling in human and rat cardiomyocytes?

Population

Human and rat cardiomyocytes, and HeLa cells stably transfected with connexin 40, 43, or 45

Intervention

AAP10 (50 nM)

Comparator

Control conditions (normal pH 7.4) or CO2-mediated acidosis (pH 6.3) without AAP10

Outcome

Macroscopic gap junction conductance (electrical coupling) and metabolic coupling (dye transfer)surrogate

AAP10 improves gap-junctional intercellular coupling and prevents acidosis-induced uncoupling in human cardiomyocytes, specifically affecting Cx43 and Cx45 isoforms.

Discussion

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Implication

Hypothesis-generating for AAP10 in Cx43/Cx45-specific coupling; validation in human models needed before any clinical consideration.

Cite This Study

Hagen et al. (2009) studied this question.

synapsesocial.com/papers/6a203af5cb26ec8ce28fd28d https://doi.org/10.1093/cvr/cvp028

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Human cardiac gap-junction coupling: effects of antiarrhythmic peptide AAP10

Structured PICO

Discussion

Implication

Cite This Study

Human cardiac gap-junction coupling: effects of antiarrhythmic peptide AAP10

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider