Key points are not available for this paper at this time.
The knock-on effect of a single catalytic reaction by a specific enzyme on a prodrug platform initiates the sequential collapse of the whole array to release the active drug units (see scheme). Such a dendritic system may provide a means to improve selective chemotherapeutic approaches in cancer therapy. Supporting information for this article is available on the WWW under http: //www. wiley-vch. de/contents/jc₂002/2005/z461657ₛ. pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Haba et al. (Tue,) studied this question.