Key result
Patients with prior myocardial infarction and LVEF <35% had a slower VO2 time constant during constant work rate exercise than those with LVEF ≥35% (58.0 vs 45.8 seconds, P=0.0002).
Why the study?
Does severely impaired left ventricular function (LVEF < 35%) affect the early dynamics of oxygen uptake (VO2) during exercise in patients with prior myocardial infarction?
Observational (n=40)
Does severely impaired left ventricular function (LVEF < 35%) affect the early dynamics of oxygen uptake (VO2) during exercise in patients with prior myocardial infarction?
Absolute Event Rate: 58% vs 45.8%
p-value: p=0.0002
The time constant of oxygen uptake during submaximal constant work rate exercise is a sensitive measure of impaired cardiac reserve in patients with prior myocardial infarction and reduced ejection fraction.
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May indicate impaired cardiac reserve in post-MI LVEF<35%; hypothesis-generating for VO2 kinetics in assessment.
Koike et al. (1994) conducted an observational in Prior myocardial infarction (n=40). LVEF < 35% vs. LVEF ≥ 35% was evaluated on VO2 time constant during constant work rate exercise (p=0.0002). Patients with prior myocardial infarction and LVEF <35% had a slower VO2 time constant during constant work rate exercise than those with LVEF ≥35% (58.0 vs 45.8 seconds, P=0.0002).
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