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Case report describes increased uptake of 68Ga-FAPI-04 in brain infarction, suggesting its inclusion in lesion diagnosis.
FAPI PET/CT is a promising imaging tool for the assessment of brain tumors due to very low FAPI uptake of normal brain parenchyma and a high target-to-background ratio. However, FAPI uptake has been observed in nonmalignant brain diseases. We describe 68 Ga-FAPI-04 PET/CT findings in a patient with chronic hemorrhagic occipital infarction. The infarcted area showed inhomogeneous 68 Ga-FAPI-04 uptake mimicking malignancy. This case indicates that brain infarction should be included in the differential diagnosis of FAPI-avid brain lesions.
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Liu et al. (2025) studied this question.
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