Key result
Older age was associated with higher forearm venous plasma noradrenaline concentrations but identical plasma clearance compared to young healthy subjects.
Why the study?
Does age affect plasma clearance of noradrenaline in healthy subjects?
Observational (n=13)
Does age affect plasma clearance of noradrenaline in healthy subjects?
Plasma clearance of noradrenaline remains unchanged with age, suggesting higher plasma concentrations in the elderly are due to increased sympathetic nervous activity.
Higher noradrenaline in older adults may reflect increased sympathetic activity with preserved clearance; hypothesis-generating and should not yet change practice.
Noradrenaline kinetics (plasma concentrations, plasma clearance and appearance rates) were investigated in seven elderly healthy subjects and in six young healthy subjects. Forearm venous plasma noradrenaline concentrations were higher in the elderly subjects compared with the young subjects. Plasma clearance of noradrenaline was identical in the two groups. The increase in plasma noradrenaline concentration, with age, probably reflects an increased sympathetic nervous activity.
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Hilsted et al. (1985) conducted an observational in Healthy subjects (n=13). Older age vs. Young age was evaluated on Noradrenaline kinetics (plasma concentrations, plasma clearance and appearance rates). Older age was associated with higher forearm venous plasma noradrenaline concentrations but identical plasma clearance compared to young healthy subjects.
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