June 12, 2007Cardiology in Review
Cardiovascular Drug Therapy in the Elderly
Key result
This review outlines pharmacokinetic and pharmacodynamic changes in aging and provides guidance on the prudent use, adverse effects, and avoidance of specific cardiovascular medications in the elderly.
Population
Elderly patients
Design
Review
Authors
Discussion
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Member takes
Implication
May guide age-adjusted CV drug selection in elderly; extends prior syntheses but leaves open need for prospective validation.
Structured PICO
P
Population
Elderly patients
I
Intervention
Cardiovascular drugs including digoxin, diuretics, beta-adrenergic blockers, angiotensin-converting enzyme inhibitors, angiotensin-II receptor blockers, nitrates, calcium channel blockers, alpha-adrenergic blockers, antiarrhythmic drugs, lipid-lowering drugs, and anticoagulants
This review highlights the pharmacokinetic and pharmacodynamic changes in the elderly that necessitate careful selection and dosing of cardiovascular medications.
Cite This Study
Aronow et al. (2007) conducted a review in Cardiovascular disease in the elderly. Cardiovascular drugs was evaluated. This review outlines pharmacokinetic and pharmacodynamic changes in aging and provides guidance on the prudent use, adverse effects, and avoidance of specific cardiovascular medications in the elderly.