The development of versatile scanning probe methods such as atomic force microscopy (AFM) makes it today possible to study bio-adhesion on a single molecule level. In this paper, we present AFM-force-spectroscopy experiments on complementary DNA strands. From such experiments, intrinsic thermodynamical properties (energy landscape) of these weak non covalent bonds can be determined.
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Grange et al. (2001) studied this question.
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