Key result
Effective quinidine therapy in patients with ventricular tachycardia resulted in decreased numbers of extrema on body surface mapping in 43% of patients compared to 14% with ineffective therapy (p=0.02).
Why the study?
Does QRST isointegral body surface mapping predict the efficacy of oral quinidine therapy in preventing ventricular tachycardia induction?
Population
51 patients with inducible ventricular tachycardia undergoing programmed stimulation studies, and 51 age…
Comparison
Oral quinidine therapy evaluated by isointegral… vs Baseline mapping and normal subjects
Design
Cohort
Authors
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May support noninvasive prediction of quinidine efficacy in VT; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=102)
Does QRST isointegral body surface mapping predict the efficacy of oral quinidine therapy in preventing ventricular tachycardia induction?
Absolute Event Rate: 43% vs 14%
p-value: p=0.02
QRST isointegral body surface mapping shows promise as a noninvasive tool to predict the efficacy of antiarrhythmic drugs like quinidine in patients with ventricular tachycardia.
Mitchell et al. (1992) conducted an observational in Ventricular tachycardia (n=102). Oral quinidine therapy vs. Ineffective therapy was evaluated on Drug-induced decreases in numbers of extrema on body surface mapping (p=0.02). Effective quinidine therapy in patients with ventricular tachycardia resulted in decreased numbers of extrema on body surface mapping in 43% of patients compared to 14% with ineffective therapy (p=0.02).
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