May 3, 2016PLoS ONEOpen Access

Young Adult Exposure to Cardiovascular Risk Factors and Risk of Events Later in Life: The Framingham Offspring Study

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Why the study?

Does early adult exposure to non-optimal cardiovascular risk factors increase the risk of coronary heart disease events later in life in a community-based cohort?

Population

4,860 participants from the Framingham Offspring Study without prior myocardial infarction or stroke…

Comparison

Early adult exposure to cardiovascular risk… vs Optimal levels of early adult risk factor…

Design

Cohort

Follow-up

average 24.5 years after age 40

Authors

MPMark J. PletcherPreventive Cardiology EVEric VittinghoffElectrophysiology ATAnusorn ThanataveeratStichting tot Steun VCVGZ

Discussion

Member takes

Implication

Supports attention to early adult risk factors; hypothesis-generating for cumulative exposure and leaves open trial confirmation.

Structured PICO

Does early adult exposure to non-optimal cardiovascular risk factors increase the risk of coronary heart disease events later in life in a community-based cohort?

Population

4,860 participants from the Framingham Offspring Study without prior myocardial infarction or stroke, followed beyond age 40, mean age at first examination 36.5 years, 48% male.

Intervention

Early adult (age 20-39 years) exposure to cardiovascular risk factors (systolic and diastolic blood pressure, LDL and HDL cholesterol) estimated via trajectory analysis.

Comparator

Optimal levels of early adult risk factor exposure (e.g., DBP ≤70 mmHg, LDL ≤100 mg/dl) with adjustment for later life (age 40+) risk factor exposures.

Outcome

Incident coronary heart disease (CHD) events, defined as myocardial infarction (recognized, unrecognized or silent) or CHD death, after age 40.hard clinical

Estimated early adult exposures to non-optimal diastolic blood pressure and LDL cholesterol are independently associated with coronary heart disease events later in life, suggesting the importance of early risk factor management.

Cite This Study

Pletcher et al. (2016) studied this question.

synapsesocial.com/papers/6a204203ea451a7974f7b3f2 https://doi.org/10.1371/journal.pone.0154288

Topics

Women and heart disease

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Young Adult Exposure to Cardiovascular Risk Factors and Risk of Events Later in Life: The Framingham Offspring Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Young Adult Exposure to Cardiovascular Risk Factors and Risk of Events Later in Life: The Framingham Offspring Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider