Key result
Late-life cardiovascular risk factor values showed substantial redistribution compared to midlife values, with 65% of men changing systolic blood pressure quartiles over 25 years.
Why the study?
Do cardiovascular risk factor values measured in elderly men represent their midlife values measured 25 years earlier?
Population
1,604 elderly men aged 70-90 years from the Honolulu Heart Program cohort, who were free of clinically…
Design
Cohort
Follow-up
25 years
Authors
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Late-life risk factor values may not represent midlife exposure in men; leaves open their validity as lifelong proxies in outcome studies.
Cohort (n=1,604)
Do cardiovascular risk factor values measured in elderly men represent their midlife values measured 25 years earlier?
Cardiovascular risk factor values measured late in life may not accurately represent lifelong exposure values due to substantial redistribution between midlife and old age.
Benfante et al. (1994) conducted a cohort in Cardiovascular disease risk factors (n=1,604). Late-life cardiovascular risk factor measurement vs. Midlife cardiovascular risk factor measurement was evaluated on Change in quartile or classification of cardiovascular risk factors (systolic blood pressure, diastolic blood pressure, body mass index, smoking, alcohol intake). Late-life cardiovascular risk factor values showed substantial redistribution compared to midlife values, with 65% of men changing systolic blood pressure quartiles over 25 years.
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