Why the study?
Does Angiotensin II regulate serotonin release and synthesis in brain neuron terminals?
Does Angiotensin II regulate serotonin release and synthesis in brain neuron terminals?
Angiotensin II exerts a biphasic, dose-dependent regulation on serotonin release and synthesis in the brain.
Hypothesis-generating for RAS-serotonin brain interactions; leaves open human translation and clinical relevance.
Angiotensin II released serotonin from neuron terminals and accelerated synthesis of the serotonin. This increase in synthesis depended on the activation of tryptophan hydroxylase. A biphasic effect was observed: at high doses the stimulatory effect depended on conversion of angiotensin II to angiotensin III. At low doses an inhibitory effect was found, possible dependent on an angiotensin II metabolite. These actions represent a subtle regulation of the open-loop serotonin system.
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Nahmod et al. (1978) studied this question.
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