Population
77 male Sprague-Dawley rats (perfused slices of medulla and hypothalamus)
Comparison
Perfusion with angiotensin II or angiotensin- vs Perfusion with Krebs' solution alone (control)
Design
Preclinical
Authors
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Should not alter hypertension management; leaves open distinct central roles for angiotensin II versus angiotensin-(1-7).
Angiotensin II and angiotensin-(1-7) exert differential effects on the release of substance P and norepinephrine in the medulla and hypothalamus, suggesting distinct functional roles in central cardiovascular regulation.
Diz et al. (1992) studied this question.
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