Key result
Inactin anesthesia resulted in significantly higher proximal tubular compliance compared to halothane anesthesia in rats (P<0.001), with no difference between hypertensive and normotensive rats.
p-value: p=<0.001
The choice of anesthetic significantly affects proximal tubular compliance in rats, while hypertension status does not.
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Anesthetic choice must be accounted for in rat renal studies; leaves open translation to human hypertension research.
Leyssac et al. (1986) studied Normotension and spontaneous hypertension (n=48). Inactin anesthesia vs. Halothane anesthesia was evaluated on Proximal tubular compliance (p=<0.001). Inactin anesthesia resulted in significantly higher proximal tubular compliance compared to halothane anesthesia in rats (P<0.001), with no difference between hypertensive and normotensive rats.
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