Population
Whole cell voltage and current clamped guinea pig ventricular myocytes dialysed with indo-1
Comparison
Inhibition of Na-Ca2+ exchanger using lithium… vs Activation of INa without exchanger inhibition
Design
Preclinical
Authors
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Supports reverse NCX as mediator of INa-triggered Ca2+ release in cardiomyocytes; extends mechanistic models but leaves human translation open.
Activation of the sodium current promotes calcium entry into cardiac cells via reverse mode Na(+)-Ca2+ exchange, triggering calcium release from the sarcoplasmic reticulum.
Lévesque et al. (1994) studied this question.
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