Key result
The T102C 5-HT2A polymorphism was not significantly associated with a history of suicide attempts in schizophrenic patients (C allele frequency 51.2% vs 47.8%, p=0.6).
Why the study?
Is the 5-HT2A gene polymorphism (102T/C) associated with suicidal behavior in schizophrenic patients?
Case-Control (n=214)
No
Is the 5-HT2A gene polymorphism (102T/C) associated with suicidal behavior in schizophrenic patients?
Absolute Event Rate: 51.2% vs 47.75%
p-value: p=0.6
The 5-HT2A gene polymorphism (102T/C) does not appear to be involved in genetic susceptibility to suicidal behavior in schizophrenic patients.
No change to suicide risk assessment in schizophrenia; leaves open other 5-HT2A variants or larger cohorts.
The objective of this study was to examine the association between the serotonin (5-HT)2A gene polymorphism (102T/C) and suicidal behavior in schizophrenic inpatients. We studied 129 subjects who met the diagnostic criteria for schizophrenia according to a structured clinical interview (MINI-PLUS). Patients underwent a semistructured interview to assess suicide attempt history and its characteristics. In addition, at least one close relative of the patient was interviewed to assess proband and family suicidal behavior. Healthy controls were students and hospital staff members free of psychiatric and medical illness. Genotypes were determined after polymerase chain reaction amplification of the region of 5-HT(2A)/T102C containing the polymorphic site and digestion with the restriction enzyme Hpall. We found no association between suicidal attempt history and suicide attempt characteristics and genotypic or allele frequencies. Suicidal behavior was also not associated with demographic or psychopathological characteristics. These results suggest that the 5-HT(2A) gene polymorphism (102T/C) is not involved in genetic susceptibility to suicidal behavior, but further studies in a larger sample are needed.
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Corrêa et al. (2007) conducted a case-control in Schizophrenia (n=214). T102C 5-HT2A polymorphism vs. Non-suicidal schizophrenic patients was evaluated on C allele frequency in patients with vs without a history of suicide attempts (p=0.6). The T102C 5-HT2A polymorphism was not significantly associated with a history of suicide attempts in schizophrenic patients (C allele frequency 51.2% vs 47.8%, p=0.6).
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