Key result
Severe sleep-disordered breathing linked to ~4.7-fold higher MACE risk in hemodialysis patients.
Why the study?
It is unclear whether the severity of sleep-disordered breathing affects the risk of cardiovascular events and mortality in patients undergoing hemodialysis.
Does severe sleep-disordered breathing increase the risk of major adverse cardiovascular events and mortality in patients undergoing maintenance hemodialysis?
Cohort (n=134)
No
Does severe sleep-disordered breathing increase the risk of major adverse cardiovascular events and mortality in patients undergoing maintenance hemodialysis?
Hazard Ratio: 4.66 (95% CI 1.87–11.61)
p-value: p=0.001
Assessing sleep-disordered breathing severity via simple overnight pulse oximetry can identify hemodialysis patients at high risk for major adverse cardiovascular events and mortality.
May support oximetry-based risk stratification in hemodialysis; leaves open whether treating severe SDB reduces events.
It is unclear whether the severity of sleep-disordered breathing (SDB) affects the risk of cardiovascular events and mortality in patients undergoing hemodialysis (HD). We determined the severity of SDB with the 3% oxygen desaturation index (ODI) via overnight pulse oximetry. This study was a retrospective cohort, observational study of 134 patients on maintenance HD at a single center. They were divided into four groups according to SDB severity (normal, mild, moderate, and severe), and were followed. The baseline characteristics of all patients were as follows: the median age was 67 (interquartile range, 59–75) years, 64.2% were men, 37.3% were diabetic, and the median duration of HD was 69 (29–132) months. During follow-up, major adverse cardiovascular events (MACEs) occurred in 71 patients and deaths in 60 (including 32 cardiovascular deaths). Severe SDB was an independent risk factor for MACEs (hazard ratio [HR] = 4.66, 95% confidence interval [CI] = 1.87–11.61, p = 0.001) and all-cause death (HR = 5.74, 95% CI = 1.92–16.70, p = 0.001). Severe SDB had a statistically significant impact on the risk of MACEs and mortality in patients undergoing HD. The severity of the 3% ODI via overnight pulse oximetry may be a useful marker as a risk factor for cardiovascular outcomes and mortality in these patients.
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Mochida et al. (2023) conducted a cohort in Maintenance hemodialysis (n=134). Severe sleep-disordered breathing (≥30 events/hour of 3% ODI) vs. Normal sleep-disordered breathing (<5 events/hour of 3% ODI) was evaluated on Major adverse cardiovascular events (MACEs) (HR 4.66, 95% CI 1.87-11.61, p=0.001). Severe sleep-disordered breathing significantly increased the risk of major adverse cardiovascular events (HR 4.66) and all-cause death compared to normal breathing in patients undergoing hemodialysis.
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