Key result
Normotensive pregnancy was associated with blunted systemic neurocardiovascular transduction, showing reduced peak mean pressure following quadruplet SNA bursts (3.0 vs 5.5 mmHg, P<0.05).
Why the study?
To test the hypothesis that pregnant women have blunted neurocardiovascular transduction despite sympathetic nervous system hyperactivity.
Does normotensive pregnancy blunt systemic neurocardiovascular transduction compared to the non-pregnant state?
Population
18 pregnant women in their third trimester and 18 age- and BMI-matched non-pregnant women
Comparison
Pregnant vs non-pregnant women
Design
Case-control study
Authors
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May indicate protective autonomic adaptation; leaves open role in gestational hypertension.
Cross-Sectional (n=36)
Does normotensive pregnancy blunt systemic neurocardiovascular transduction compared to the non-pregnant state?
Absolute Event Rate: 3% vs 5.5%
p-value: p=<0.05
Normotensive pregnancy is associated with blunted systemic neurocardiovascular transduction, which may serve as a protective adaptation against sympathetic hyperactivity.
Steinback et al. (2019) conducted a cross-sectional in Normotensive pregnancy (n=36). Normotensive pregnancy vs. Non-pregnant state was evaluated on Peak mean pressure in relation to sequences of SNA bursts (quadruplets) (p=<0.05). Normotensive pregnancy was associated with blunted systemic neurocardiovascular transduction, showing reduced peak mean pressure following quadruplet SNA bursts (3.0 vs 5.5 mmHg, P<0.05).
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