Key result
Platelet activation and aggregation significantly increased during carotid endarterectomy (P<0.01), while Dextran 40 infusion in high-risk patients decreased P-selectin expression at 24 hours (P<0.01).
Why the study?
Does Dextran 40 reduce platelet activation in patients undergoing carotid endarterectomy who experience frequent high intensity transient signals?
Population
40 patients undergoing carotid endarterectomy. All patients received aspirin preoperatively and 5,000 units…
Comparison
Dextran 40 infusion. vs Baseline/pre-infusion levels.
Design
Cohort
Follow-up
Perioperative and 24 hours post-infusion
Authors
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May support Dextran 40 to blunt platelet activation in high-HITS CEA; leaves open effects on clinical events.
Observational (n=40)
Does Dextran 40 reduce platelet activation in patients undergoing carotid endarterectomy who experience frequent high intensity transient signals?
p-value: p=<0.01
Significant platelet activation occurs during carotid endarterectomy despite standard antiplatelet therapy, and Dextran 40 infusion effectively reduces this activation in patients with frequent microemboli.
Robless et al. (2002) conducted an observational in Carotid endarterectomy (n=40). Carotid endarterectomy and Dextran 40 vs. Preoperative baseline was evaluated on Platelet activation (P-selectin and PAC-1 expression) and aggregation (p=<0.01). Platelet activation and aggregation significantly increased during carotid endarterectomy (P<0.01), while Dextran 40 infusion in high-risk patients decreased P-selectin expression at 24 hours (P<0.01).
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