Key result
Aortic valve replacement improved left ventricular function and reduced hypertrophy, but did not normalize left ventricular volumes or mass index within 1 year.
Why the study?
Does surgical aortic valve replacement improve left and right ventricular function and mass in patients with aortic stenosis?
Observational (n=28)
Does surgical aortic valve replacement improve left and right ventricular function and mass in patients with aortic stenosis?
Surgical aortic valve replacement for aortic stenosis improves LV function and reduces hypertrophy, but LV volumes and mass index may not fully normalize within 1 year.
The purpose of this study was to determine the changes in function of both the left and the right ventricles (LV, RV) before and after aortic valve replacement (AVR), compared with age-matched healthy volunteers using magnetic resonance (MR) imaging. Fourteen patients with aortic stenosis underwent MR imaging (1.5 T) before and 3 (n = 14) and 12 (n = 9) months after surgical valve replacement. An electrocardiographically triggered two-dimensional cine fast low-angle shot sequence was used for the evaluation of absolute values and indices related to 1 m2body surface area for function, mass, and LV wall thickening. Fourteen age-matched healthy volunteers served as controls. Before surgery, all patients showed significant abnormalities of LV mass and function, whereas RV mass and function were not different from those of volunteers and remained mostly unchanged. After surgery, normalization of LV ejection fraction, absolute mass, and end-systolic wall thickness was observed, whereas the LV mass index failed to normalize, and LV volumes remained elevated. Aortic stenosis combined with a significant, but not severe reduction in LV function only affects the LV, whereas the RV remains unaffected at this stage of disease. AVR leads to improved LV function and reduced hypertrophy, but without normalization of LV volumes or the LV mass index within 1 year. J. Magn. Reson. Imaging 2000;12:240–246.
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Sandstede et al. (2000) conducted an observational in Aortic stenosis (n=28). Aortic valve replacement vs. Pre-surgery baseline and healthy volunteers was evaluated on Changes in left and right ventricular function, mass, and wall thickening. Aortic valve replacement improved left ventricular function and reduced hypertrophy, but did not normalize left ventricular volumes or mass index within 1 year.
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