Genome-wide association study uncovers genetic links to severe asthma exacerbations in a diverse Brazilian population, suggesting areas for further research.
Background: Asthma exacerbations are episodes of symptom worsening requiring increased therapy, which affect patients across all asthma severities. Potential genetic associations with asthma exacerbations in an understudied population were investigated. Objective: We sought to perform a genome-wide association study on severe asthma exacerbations in an admixed adult population with varying asthma severities and to explore potential epigenetic roles. Methods: via PhenoScanner v2. Results: ). Conclusions: The CXADR is highlighted as a potential novel susceptibility locus for asthma exacerbations, possibly tied to viral respiratory infections. Further replication and validation are needed.
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Santana et al. (2025) studied this question.
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