Key result
Elevated ankle blood pressure was significantly associated with an increased risk of incident cerebrovascular events (HR 2.24; 95% CI 1.43-3.52; P < .0001).
Why the study?
Does elevated ankle blood pressure predict incident cerebrovascular morbidity and mortality?
Cohort (n=3,808)
Does elevated ankle blood pressure predict incident cerebrovascular morbidity and mortality?
Hazard Ratio: 2.24 (95% CI 1.43–3.52)
p-value: p=< .0001
Elevated ankle blood pressure is a superior risk marker compared to pulse pressure for predicting future cerebrovascular events.
May support ankle BP over pulse pressure for cerebrovascular risk stratification; leaves open validation before clinical use.
Background and Objective. We examined the association of elevated ankle blood pressure (ABP), together with exercise blood pressure, with incident cerebrovascular (CV) morbidity and mortality in a prospective follow-up study of 3,808 patients. The results were compared with pulse pressure, another indicator of arterial stiffness. Methods. Patients with normal ankle and exercise brachial blood pressures were taken as the reference group. Pulse pressure was considered as quartiles with the lowest quartile as the reference category. Results. A total of 170 subjects had a CV event during the follow-up. Multivariate adjusted hazard ratio of a CV event was 2.24 (95% CI 1.43-3.52, P < .0001) in patients with abnormal ABP. The pulse pressure was significant only in the model adjusted for age and sex. Conclusion. The risk of a future CV event was elevated already in those patients among whom elevated ABP was the only abnormal finding. As a risk marker, ABP is superior to the pulse pressure.
No takes yet. Share an insight, caveat, or question.
Hietanen et al. (2010) conducted a cohort in Cerebrovascular morbidity and mortality (n=3,808). Elevated ankle blood pressure (ABP) vs. Normal ankle and exercise brachial blood pressures was evaluated on Incident cerebrovascular (CV) morbidity and mortality (HR 2.24, 95% CI 1.43-3.52, p=< .0001). Elevated ankle blood pressure was significantly associated with an increased risk of incident cerebrovascular events (HR 2.24; 95% CI 1.43-3.52; P < .0001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: