What question did this study set out to answer?

This research investigates the link between isolated systolic hypertension and atherosclerosis as reflected by carotid artery wall thickness.

January 1, 1993Arteriosclerosis and Thrombosis A Journal of Vascular BiologyOpen Access

Isolated systolic hypertension and vessel wall thickness of the carotid artery. The Rotterdam Elderly Study.

View Full Paper

Ask AI

Bookmark

Why the study?

Is isolated systolic hypertension associated with increased carotid intima-media thickness in elderly persons?

Key Points

This research investigates the link between isolated systolic hypertension and atherosclerosis as reflected by carotid artery wall thickness.
Single-center cohort study involving 11,854 elderly participants aged 55+
Ultrasonic evaluation of intima-media thickness and carotid artery lumen diameter
Comparison between individuals with isolated systolic hypertension and matched control subjects
Mean IMT was 0.07 mm higher in ISH subjects compared to controls (95% CI, 0.01, 0.14)
Mean lumen diameter was 0.70 mm larger in ISH subjects for the right carotid artery (95% CI, 0.38, 1.01) and 0.48 mm larger for left (95% CI, 0.17, 0.80)
12% more atherosclerotic plaques observed in ISH subjects compared to controls (95% CI, -1, 25)

Structured PICO

Is isolated systolic hypertension associated with increased carotid intima-media thickness in elderly persons?

Population

99 elderly persons ≥ 55 years old (33 with isolated systolic hypertension and 66 age- and sex-matched normotensive controls), not on antihypertensive drugs and free of cardiovascular disease, from the Rotterdam Elderly Study.

Intervention

Isolated systolic hypertension (systolic pressure ≥ 160 mm Hg and diastolic pressure < 90 mm Hg)

Comparator

Normotensive age- and sex-matched control subjects

Outcome

Intima-media wall thickness (IMT) of the distal common carotid arterysurrogate

Isolated systolic hypertension in the elderly is associated with increased carotid intima-media thickness and larger lumen diameter, indicating an association with generalized atherosclerosis.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May reflect vascular effects of ISH in elderly; extends observational data but requires validation in longitudinal studies.

Cite This Study

Bots et al. (1993) studied this question.

synapsesocial.com/papers/6a2052d74ad5e85db1e722f2 https://doi.org/10.1161/01.atv.13.1.64

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Isolated systolic hypertension and vessel wall thickness of the carotid artery. The Rotterdam Elderly Study.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Isolated systolic hypertension and vessel wall thickness of the carotid artery. The Rotterdam Elderly Study.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider