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February 1, 1971Acta Physiologica Scandinavica

The Time Course of the Active State in Relation to Sarcomere Length and Movement Studied in Single Skeletal Muscle Fibres of the Frog

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Population

Single semitendinosus muscle fibres of the frog

Comparison

Quick-release technique at different sarcomere… vs Different sarcomere lengths and isometric…

Design

Preclinical

Authors

KEK. A. P. EdmanAstraZeneca (Sweden)AKAnders KiesslingAnimal Welfare Institute

Discussion

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Overview

Shortening depresses active state duration in skeletal fibers; leaves open extension to cardiac sarcomere dynamics.

Structured PICO

P
Population
Single semitendinosus muscle fibres of the frog
I
Intervention
Quick-release technique at different sarcomere lengths (1.7-2.8 μ) and intervals of free shortening
C
Comparator
Different sarcomere lengths and isometric contractions without free shortening
O
Outcome
Time course of the active state (rising and falling phases, duration, tension production)surrogate

In frog skeletal muscle fibers, the duration of the active state decreases with shorter sarcomere lengths and is depressed by active shortening during contraction.

Cite This Study

Edman et al. (1971) studied this question.

synapsesocial.com/papers/6a20538089a9728653d1f337https://doi.org/10.1111/j.1748-1716.1971.tb04891.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The relation between sarcomere length and active tension in isolated semitendinosus fibres of the frog1966 · 128 citations
  2. 2The abrupt transition from rest to activity in muscle1949 · 479 citations
  3. 3The Site of Calcium Binding in Relation to the Activation of Myofibrillar Contraction1968 · 111 citations
  4. 4Striated Muscle Fibers: Inactivation of Contraction Induced by Shortening1970 · 132 citations
  5. 5Onset of contractility in cardiac muscle1966 · 100 citations