Population
Isolated semitendinosus fibres of the frog
Comparison
Different degrees of prestretch and active… vs Passive extension at rest vs active shortening…
Design
Preclinical
Key result
The capacity of isolated frog semitendinosus fibres to produce tension is determined by actual sarcomere spacing, supporting the sliding-filament hypothesis of muscular contraction.
Authors
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No immediate clinical implications; leaves open translation of sarcomere mechanics to human myocardium.
The study provides physiological evidence supporting the sliding-filament hypothesis of muscular contraction by demonstrating that tension output is determined by actual sarcomere spacing regardless of previous length changes.
K. A. P. Edman (1966) studied this question. Prestretch and active shortening was evaluated on Relation between sarcomere length and tetanic tension. The capacity of isolated frog semitendinosus fibres to produce tension is determined by actual sarcomere spacing, supporting the sliding-filament hypothesis of muscular contraction.