What does this research mean for the field?

While changes in the overlap zone of A and I filaments during stretch and shortening are consistent with the sliding filament model, the model cannot explain the observed decreases in filament length during isometric contraction or the development of tension at extreme stretch where a gap exists between filaments. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

October 1, 1961The Journal of Cell BiologyOpen Access

Ultrastructure of the Resting and Contracted Striated Muscle Fiber at Different Degrees of Stretch

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Population

Striated, non-glycerinated frog muscle fibers

Comparison

Passive stretch, isometric contraction, and… vs Resting state and varying degrees of stretch

Design

Preclinical

Authors

FCF. CarlsenUniversity of Copenhagen GKG. G. KnappeisUniversity of Copenhagen FBFritz BuchthalUniversity of Copenhagen

Discussion

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Implication

Challenges sliding filament model at isometric contraction and extremes; leaves open sarcomere mechanics mechanisms for further study.

Structured PICO

Population

Striated, non-glycerinated frog muscle fibers

Intervention

Passive stretch, isometric contraction, and shortening

Comparator

Resting state and varying degrees of stretch

Outcome

Ultrastructural changes including sarcomere length, fiber diameter, filament length, and overlap zonesurrogate

Ultrastructural analysis of frog muscle fibers reveals changes in filament overlap consistent with the sliding filament model, but identifies discrepancies during isometric contraction and extreme stretch.

Cite This Study

Carlsen et al. (1961) studied this question.

synapsesocial.com/papers/6a1d8a4da44061a0895dcc9c https://doi.org/10.1083/jcb.11.1.95

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Ultrastructure of the Resting and Contracted Striated Muscle Fiber at Different Degrees of Stretch

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ultrastructure of the Resting and Contracted Striated Muscle Fiber at Different Degrees of Stretch

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider