Key result
Influenza infection was not a significant predictor of recent AMI after adjustment, whereas influenza vaccination was significantly protective (OR 0.55; 95% CI 0.35-0.85).
Why the study?
Is influenza infection a significant precipitant of acute myocardial infarction, and does influenza vaccination offer protection?
Population
559 participants at a tertiary referral hospital in Sydney, Australia, comprising 275 inpatients with acute…
Comparison
Influenza infection and influenza vaccination vs No influenza infection and no influenza…
Design
Case-control
Authors
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Vaccination associated with lower AMI odds; leaves open causality and infection's precipitant role.
Case-Control (n=559)
No
Is influenza infection a significant precipitant of acute myocardial infarction, and does influenza vaccination offer protection?
Odds Ratio: 1.97 (95% CI 1.09–3.54)
Absolute Event Rate: 12.4% vs 6.7%
Influenza vaccination provides significant protection against acute myocardial infarction, highlighting an underused preventive strategy for patients at risk of ischemic heart disease.
MacIntyre et al. (2013) conducted a case-control in Acute myocardial infarction (n=559). Acute myocardial infarction (cases) vs. No acute myocardial infarction (controls) was evaluated on Laboratory evidence of influenza (OR 1.97, 95% CI 1.09 to 3.54). Influenza infection was not a significant predictor of recent AMI after adjustment, whereas influenza vaccination was significantly protective (OR 0.55; 95% CI 0.35-0.85).
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