May 24, 2006Epidemiology
Perceived Stress and Risk of Ischemic Heart Disease
Key result
High levels of perceived stress were associated with a slightly higher risk of incident ischemic heart disease in both women (HR 1.23) and men (HR 1.25), driven primarily by angina pectoris.
Why the study?
Does high perceived stress increase the risk of incident ischemic heart disease in men and women?
Population
11,839 men and women participating in the Copenhagen City Heart Study
Comparison
High levels of perceived stress vs Lower levels of perceived stress
Design
Cohort
Follow-up
From baseline (1981-1983) until the year 2000
Authors
Discussion
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Member takes
Implication
May reflect reporting bias for angina rather than true MI risk; hypothesis-generating and should not yet change practice.
Study Design
Type
Cohort (n=11,839)
Structured PICO
Does high perceived stress increase the risk of incident ischemic heart disease in men and women?
P
Population
11,839 men and women from the Copenhagen City Heart Study followed for up to 19 years to assess the association between perceived stress and incident ischemic heart disease.
E
Exposure
High levels of perceived stress
C
Comparator
Lower levels of perceived stress
O
Outcome
First incidence of ischemic heart diseasehard clinical
Main Result
Effect estimate: HR 1.23 for women, HR 1.25 for men (95% CI 1.01-1.51 for women, 1.00-1.56 for men)
High perceived stress is associated with an increased risk of incident ischemic heart disease, but this appears to be driven by reporting bias related to angina pectoris rather than a true increase in myocardial infarction.
Limitations
- Potential reporting bias due to a tendency for stressed individuals to report more cardiovascular symptoms
- Associations attenuated with prolonged follow-up
- Potential reporting bias for cardiovascular symptoms
- Attenuation of associations with prolonged follow-up
Cite This Study
Rod et al. (2006) conducted a cohort in Ischemic heart disease (n=11,839). High levels of perceived stress vs. Lower levels of stress was evaluated on First incidence of ischemic heart disease (HR 1.23 for women, HR 1.25 for men, 95% CI 1.01-1.51 for women, 1.00-1.56 for men). High levels of perceived stress were associated with a slightly higher risk of incident ischemic heart disease in both women (HR 1.23) and men (HR 1.25), driven primarily by angina pectoris.