Key result
Substantial weight loss in obese subjects significantly decreased P wave dispersion (p<0.001), with a greater decrease in those losing ≥12% of their weight (21 vs 7 ms, p<0.002).
Why the study?
Does a 12-week weight loss program improve P wave dispersion in obese subjects?
Observational (n=30)
Does a 12-week weight loss program improve P wave dispersion in obese subjects?
Substantial weight loss in obese subjects is associated with a significant decrease in P wave dispersion, suggesting an improvement in atrial repolarization abnormalities.
Suggests weight loss may mitigate atrial repolarization abnormalities in obesity; hypothesis-generating, needs randomized confirmation before practice change.
OBJECTIVE: The aim of this study was to investigate effect of loss weight on P wave dispersion in obese subjects. RESEARCH METHODS AND PROCEDURES: After a 12-week weight loss program (diet and medical therapy), a total of 30 (24 women and six men) obese subjects who had lost at least 10% of their original weight were included in the present study. All subjects underwent a routine standard 12-lead surface electrocardiogram. Electrocardiograms were transferred to a personal computer by a scanner and then magnified 400 times by Adobe Photoshop software (Adobe Systems, Mountain View, CA). P wave dispersion, which is also defined as the difference between the maximum P wave duration and the minimum P wave duration, was also calculated. RESULTS: After a 12-week weight loss program, BMI (p < 0.001), maximum P wave duration (p < 0.001), and P wave dispersion (p < 0.001) significantly decreased. The mean percentage of weight loss was 13% (10% to 20.3%). The decrease in the level of P wave dispersion (21 +/- 10 and 7 +/- 12 ms, p < 0.002) was more prominent in Group II (>or=12% loss of their original weight) than Group I (<12% loss of their original weight) after the weight loss program. A statistically significant correlation between decrease in the level of P wave dispersion and percentage of weight loss was found (r = 0.624, p < 0.001). DISCUSSION: Substantial weight loss in obese subjects is associated with a decrease of P wave duration and dispersion. Therefore, these observations suggest that substantial weight loss is associated with improvement in atrial repolarization abnormalities in obese subjects.
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Duru et al. (2006) conducted an observational in Obesity (n=30). Weight loss vs. Baseline and <12% weight loss was evaluated on P wave dispersion (p=<0.001). Substantial weight loss in obese subjects significantly decreased P wave dispersion (p<0.001), with a greater decrease in those losing ≥12% of their weight (21 vs 7 ms, p<0.002).
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