Determination of a Dark-Induced Increase of Pineal N-Acetyl Transferase Activity and Simultaneous Radioimmunoassay of Melatonin in Pineal, Serum and Pituitary Tissue of the Male Rat

Departments of †Pediatrics and Genetics, and *Physiology, University of Geneva, Faculty of Medicine, 1211 Geneva 4, Switzerland (Received 1 September 1976) The pineal gland has received much attention because of the controversial role of melatonin in reproduction (Minneman Ozaki, Lynch Pang, Brown, Grota Rollag & Niswender, 1976). We have described studies in which we measured dark-induced NAT and melatonin content