Key result
Inhibition of β1-AR/Gαs signaling with metoprolol promoted cardiomyocyte proliferation, reduced scar formation, and improved cardiac function after myocardial infarction in juvenile mice by activating the RhoA-YAP axis.
Why the study?
Cardiomyocyte proliferation ceases shortly after birth, and while beta-AR blockade improves heart function post-injury, the underlying mechanisms remain poorly understood.
Population
Postnatal and juvenile mice
Comparison
Inhibition of beta-AR signaling using metoprolol or genetic deletion of Gnas vs control
Design
Preclinical animal study
Authors
Loading...
Should not yet change post-MI therapy; leaves open whether β1-AR inhibition promotes regeneration in adult hearts.
Inhibiting β1-AR/Gαs signaling promotes cardiomyocyte proliferation and cardiac regeneration in juvenile mice by activating YAP-mediated transcriptional programs.
Sakabe et al. (2022) studied Myocardial infarction. Metoprolol vs. Saline was evaluated on Cardiomyocyte proliferation and cardiac function. Inhibition of β1-AR/Gαs signaling with metoprolol promoted cardiomyocyte proliferation, reduced scar formation, and improved cardiac function after myocardial infarction in juvenile mice by activating the RhoA-YAP axis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: